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Eukaryotic Cell, June 2003, p. 510-520, Vol. 2, No. 3
1535-9778/03/$08.00+0     DOI: 10.1128/EC.2.3.510-520.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Scw1p Antagonizes the Septation Initiation Network To Regulate Septum Formation and Cell Separation in the Fission Yeast Schizosaccharomyces pombe

Quan-Wen Jin and Dannel McCollum*

Department of Molecular Genetics and Microbiology and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605

Received 11 November 2002/ Accepted 6 February 2003

Cytokinesis in the fission yeast Schizosaccharomyces pombe is regulated by a signaling pathway termed the septation initiation network (SIN). The SIN is essential for initiation of actomyosin ring constriction and septum formation. In a screen to search for mutations that can rescue the sid2-250 SIN mutant, we obtained scw1-18. Both the scw1-18 mutant and the scw1 deletion mutant (scw1{Delta} mutant), have defects in cell separation. Both the scw1-18 and scw1{Delta} mutations rescue the growth defects of not just the sid2-250 mutant but also the other temperature-sensitive SIN mutants. Other cytokinesis mutants, such as those defective for actomyosin ring formation, are not rescued by scw1{Delta}. scw1{Delta} does not seem to rescue the SIN by restoring SIN signaling defects. However, scw1{Delta} may function downstream of the SIN to promote septum formation, since scw1{Delta} can rescue the septum formation defects of the cps1-191ß-1,3-glucan synthase mutant, which is required for synthesis of the primary septum.

* Corresponding author. Mailing address: University of Massachusetts Medical School, 377 Plantation St., Biotech 4, Worcester, MA 01605. Phone: (508) 856-8767. Fax: (508) 856-8774. E-mail: dannel.mccollum{at}umassmed.edu.

Eukaryotic Cell, June 2003, p. 510-520, Vol. 2, No. 3
1535-9778/03/$08.00+0     DOI: 10.1128/EC.2.3.510-520.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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