Eukaryotic Cell
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
EC.00110-07v1
6/7/1248    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Griffiths, S.
Right arrow Articles by Gull, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Griffiths, S.
Right arrow Articles by Gull, K.

 Previous Article

Eukaryotic Cell, July 2007, p. 1248-1250, Vol. 6, No. 7
1535-9778/07/$08.00+0     doi:10.1128/EC.00110-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

RNA Interference Mutant Induction In Vivo Demonstrates the Essential Nature of Trypanosome Flagellar Function during Mammalian Infection{triangledown}

Samantha Griffiths, Neil Portman, Philip R. Taylor,{dagger} Siamon Gordon, Michael L. Ginger, and Keith Gull*

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom

Received 5 April 2007/ Accepted 7 May 2007

We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.

* Corresponding author. Mailing address: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom. Phone: 44 (0) 1865 285752. Fax: 44 (0) 1865 285691. E-mail: keith.gull{at}path.ox.ac.uk

{triangledown} Published ahead of print on 18 May 2007.

{dagger} Present address: Department of Medical Biochemistry and Immunology, School of Medicine, Tenovus Building, Heath Campus, Cardiff, CF14 4XN, United Kingdom.

Eukaryotic Cell, July 2007, p. 1248-1250, Vol. 6, No. 7
1535-9778/07/$08.00+0     doi:10.1128/EC.00110-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Appl. Environ. Microbiol. Infect. Immun. J. Bacteriol.
Mol. Cell Biol. Microbiol. Mol. Biol. Rev. ALL ASM JOURNALS
Copyright © 2007 by the American Society for Microbiology.