Eukaryotic Cell
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Eukaryotic Cell, July 2008, p. 1191-1199, Vol. 7, No. 7
1535-9778/08/$08.00+0     doi:10.1128/EC.00059-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Hos2p/Set3p Deacetylase Complex Signals Secretory Stress through the Mpk1p Cell Integrity Pathway{triangledown}

T. J. Cohen,1 M. J. Mallory,2 R. Strich,2 and T.-P. Yao1*

Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710,1 Department of Molecular Biology, UMDNJ—School of Osteopathic Medicine, Stratford, New Jersey 080842

Received 14 February 2008/ Accepted 6 May 2008

Perturbations in secretory function activate stress response pathways critical for yeast survival. Here we report the identification of the Hos2p/Set3p deacetylase complex (SET3C) as an essential component of the secretory stress response. Strains lacking core components of the Hos2p/Set3p complex exhibit hypersensitivity to secretory stress. Although not required for the unfolded protein response (UPR) and ribosomal gene repression, the Hos2p complex is required for proper activation of the Mpk1p/Slt2p cell integrity kinase cascade. Disruption of the Hos2p complex results in abrogated Mpk1p phosphorylation, whereas constitutive activation of the Mpk1p pathway rescues the hos2{Delta} mutant growth defect in response to secretory stress. Furthermore, Hos2p activity is required for the Mpk1p-mediated activation of stress-responsive transcription factor Rlm1p, but not for the stress-induced degradation of the C-type cyclin Ssn8p. Our results identify the Hos2p complex as a critical component of the secretory stress response and support the existence a coordinated stress response consisting of the UPR, ribosomal gene repression, and mitogen-activated protein kinase signaling in response to defects in secretory function.

* Corresponding author. Mailing address: Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710. Phone: (919) 613-8654. Fax: (919) 681-8461. E-mail: yao00001{at}mc.duke.edu

{triangledown} Published ahead of print on 16 May 2008.

Eukaryotic Cell, July 2008, p. 1191-1199, Vol. 7, No. 7
1535-9778/08/$08.00+0     doi:10.1128/EC.00059-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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