Eukaryotic Cell
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EC Accepts, published online ahead of print on 1 August 2008
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Eukaryotic Cell doi:10.1128/EC.00155-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Regulation of cellular adhesion in Dictyostelium: involvement of Sib proteins

Sophie Cornillon, Romain Froquet, and Pierre Cosson*

Geneva Faculty of Medicine, Cell Physiology and Metabolism Department, Centre Médical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland

* To whom correspondence should be addressed. Email: Pierre.Cosson{at}medecine.unige.ch.


  Abstract

Molecular mechanisms ensuring cellular adhesion have been studied in detail in Dictyostelium amoebae, but little is known about the regulation of cellular adhesion in these cells. Here we show that cellular adhesion is regulated in Dictyostelium, notably by the concentration of a cellular secreted factor accumulating in the medium. This constitutes a quorum-sensing mechanism allowing coordinated regulation of cellular adhesion in a Dictyostelium population. In order to understand the mechanism underlying this regulation, we analyzed the expression of recently identified Dictyostelium adhesion molecules (Sib proteins) that present features also found in mammalian integrins. SibA and sibC are both expressed in vegetative Dictyostelium cells, but the expression of sibC is repressed strongly in conditions where cellular adhesion decreases. Analysis of sibA and sibC mutant cells further suggests that variations in the expression levels of sibC account largely for changes in cellular adhesion in response to environmental cues.






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