This Article Full Text (PDF) Other Versions of this Article: EC.00458-07v1 7/9/1611    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Google Scholar Articles by Castle, S. A. Articles by Levery, S. B. PubMed PubMed Citation Articles by Castle, S. A. Articles by Levery, S. B.

 Previous Article  |  Next Article 

Eukaryotic Cell doi:10.1128/EC.00458-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

The 1,2-Xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids

Department of Chemistry, University of New Hampshire, G229 Parsons Hall, Durham, NH 03824-3598, USA; Departments of Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA

^* To whom correspondence should be addressed. Email: levery{at}imbg.ku.dk.

	Abstract

A Man1,3(Xyl1,2)Man structural motif is common to both capsular polysaccharides of C. neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild type and mutant strains showed that a Xyl1,2-transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.