Eukaryotic Cell
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Eukaryotic Cell, June 2008, p. 1071-1074, Vol. 7, No. 6
1535-9778/08/$08.00+0     doi:10.1128/EC.00066-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Contributions of the Response Regulators Ssk1p and Skn7p in the Pseudohyphal Development, Stress Adaptation, and Drug Sensitivity of the Opportunistic Yeast Candida lusitaniae{triangledown} ,{dagger}

Gwenaël Ruprich-Robert, Florence Chapeland-Leclerc, Stéphanie Boisnard, Martine Florent, Gaël Bories, and Nicolas Papon*

Programme Chimiorésistance des Levures Pathogènes, EA209 Eucaryotes Pathogènes: Transports Membranaires et Chimiorésistance, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 75006 Paris, France

Received 18 February 2008/ Accepted 7 April 2008

We recently characterized the histidine kinase receptor genes of Candida lusitaniae. For the present study, we have further investigated the role of SSK1 and SKN7, encoding response regulators. The results of functional analysis of mutants indicated that Ssk1p is involved in osmotolerance and pseudohyphal development, whereas Skn7p appears crucial for oxidative stress adaptation.

* Corresponding author. Mailing address: Programme Chimiorésistance des Levures Pathogènes, EA209 Eucaryotes Pathogènes: Transports Membranaires et Chimiorésistance, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 4 Avenue de l'Observatoire, 75006 Paris, France. Phone: (33) 1 53 73 96 42. Fax: (33) 1 53 73 96 40. E-mail: nicolas.papon{at}univ-paris5.fr

{triangledown} Published ahead of print on 11 April 2008.

{dagger} Supplemental material for this article may be found at http://ec.asm.org/.

Eukaryotic Cell, June 2008, p. 1071-1074, Vol. 7, No. 6
1535-9778/08/$08.00+0     doi:10.1128/EC.00066-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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