Eukaryotic Cell
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Eukaryotic Cell, September 2008, p. 1606-1610, Vol. 7, No. 9
1535-9778/08/$08.00+0     doi:10.1128/EC.00200-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Calcineurin Localizes to the Hyphal Septum in Aspergillus fumigatus: Implications for Septum Formation and Conidiophore Development{triangledown} ,{dagger}

Praveen Rao Juvvadi,1 Jarrod R. Fortwendel,1 Nadthanan Pinchai,1 B. Zachary Perfect,1 Joseph Heitman,2,3,4 and William J. Steinbach1,2*

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina,1 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina,2 Department of Medicine, Duke University Medical Center, Durham, North Carolina,3 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina4

Received 18 June 2008/ Accepted 23 June 2008

A functional calcineurin A fusion to enhanced green fluorescent protein (EGFP), CnaA-EGFP, was expressed in the Aspergillus fumigatus {Delta}cnaA mutant. CnaA-EGFP localized in actively growing hyphal tips, at the septa, and at junctions between the vesicle and phialides in an actin-dependent manner. This is the first study to implicate calcineurin in septum formation and conidiophore development of a filamentous fungus.

* Corresponding author. Mailing address: Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710. Phone: (919) 681-1504. Fax: (919) 684-8902. E-mail: stein022{at}mc.duke.edu

{triangledown} Published ahead of print on 7 July 2008.

{dagger} Supplemental material for this article may be found at http://ec.asm.org/.

Eukaryotic Cell, September 2008, p. 1606-1610, Vol. 7, No. 9
1535-9778/08/$08.00+0     doi:10.1128/EC.00200-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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Copyright © 2008 by the American Society for Microbiology.