Eukaryotic Cell
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EC Accepts, published online ahead of print on 23 May 2008
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Eukaryotic Cell doi:10.1128/EC.00132-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae

Oleh Khalimonchuk, Kevin Rigby, Megan Bestwick, Fabien Pierrel, Paul A. Cobine, and Dennis R. Winge*

From the University of Utah Health Sciences Center, Departments of Medicine and Biochemistry, Salt Lake City, Utah 84132

* To whom correspondence should be addressed. Email: dennis.winge{at}hsc.utah.edu.


   Abstract

The twin Cx9C motif protein Pet191 is essential for cytochrome c oxidase maturation. The motif Cys residues are functionally important and appear to be present in disulfide linkages within a large oligomeric complex associated with the mitochondrial inner membrane. The import of Pet191 differs from other twin Cx9C motif class of proteins in being independent of the MIA pathway.







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