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Eukaryotic Cell doi:10.1128/EC.00200-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Calcineurin Localizes to the Hyphal Septum in Aspergillus fumigatus: Implications for Septum Formation and Conidiophore Development

Department of Pediatrics, Duke University Medical Center, Durham, NC USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC USA; Department of Medicine, Duke University Medical Center, Durham, NC USA; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC USA

^* To whom correspondence should be addressed. Email: stein022{at}mc.duke.edu.

	Abstract

A functional calcineurin A fusion to GFP (CnaA-EGFP) was expressed in the Aspergillus fumigatus cnaA mutant. CnaA-EGFP localized in actively growing hyphal tips, at the septa, and at junctions between the vesicle and phialides in an actin-dependent manner. This is the first study to implicate calcineurin in septum formation and conidiophore development of a filamentous fungus.