Cover photograph (Copyright © 2008, American Society for Microbiology. All Rights Reserved.): The wheat and glume blotch fungus Stagonospora nodorum can reproduce by forming spherical asexual fruiting bodies called pycnidia. The image consists of a longitudinal section of a pycnidium stained with the double-stranded DNA-specific stain 4′,6-diamidino-2-phenylindole dilactate (DAPI). DAPI staining revealed an abundance of nucleated cells in the pycnidial cavity that are associated with sporogenesis, compared to the level of cells in the outer pycnidial wall. The deletion of a signaling-regulated short-chain dehydrogenase severely altered pycnidial ontogeny and nuclear distribution. (See related article on page 1916.)